Cellular and genomic approaches for exploring structural chromosomal rearrangements

Rearrangements and chromosomal evolution.

Comparisons of the genome sequences of related species suggests varying patterns of chromosomal rearrangements in different evolutionary lineages. In this review, I focus on the quantitative characterization of rearrangement processes and discuss specific inventories that have been compiled to date. Of particular interest are the statistical distribution of the lengths of inverted or locally tr...

Chromosomal rearrangements and speciation.

Several authors have proposed that speciation frequently occurs when a population becomes fixed for one or more chromosomal rearrangements that reduce fitness when they are heterozygous. This hypothesis has little theoretical support because mutations that cause a large reduction in fitness can be fixed through drift only in small, inbred populations. Moreover, the effects of chromosomal rearra...

Chromosomal rearrangements in cancer

Many cancers exhibit chromosomal rearrangements. These rearrangements can be simple with a single balanced fusion preserving the proper complement of genetic information or they can be complex with one or more fusions that distort this balance. A range of technological advances has improved our ability to detect and understand these rearrangements leading to speculation of causal mechanisms inc...

Genomic Rearrangements and Evolution

Exploring and Exploiting Quantum-Dot Cellular Automata

The Full Adders (FAs) constitute the essential elements of digital systems, in a sense that they affect the circuit parameters of such systems. With respect to the MOSFET restrictions, its replacement by new devices and technologies is inevitable. QCA is one of the accomplishments in nanotechnology nominated as the candidate for MOSFET replacement. In this article 4 new layouts are presente...